DNA & RNA Synthesis
We have developed a robust synthesis technology that enables manufacturing custom microarray slides and oligonucleotide libraries at very competitive rates. Our technology begins with the synthesis of DNA oligonucleotide libraries on microarray slides. These oligos can be cleaved from the substrate and then modified for countless downstream applications. We have combined the flexibility of digital photolithography to the robustness of the phosphoramidite oligonucleotide synthesis chemistry. This enables synthesis of up to 500,000 oligonucleotides on substrates the size of a microscope slide at a very competitive cost. Since we utilize a mask-less approach, our technology is extremely flexible, making it possible to offer custom synthesis for a wide variety of applications.
We have commercialized the E. coli-based cell-free transcription and translation (TXTL) technology developed in Dr. Vincent Noireaux’s lab at the University of Minnesota. Improving the robustness and stability of the myTXTL system, allows us to deliver a consistently performing product for protein optimization or testing gene networks. We continue to advance this technology by developing TXTL systems from new host organisms and optimizing essential components for maximum expression. Additionally, we have developed proprietary solutions for generating guide RNAs and long ssDNA homology-directed repair (HDR) templates utilized in CRISPR-mediated genome editing.